Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis
Identifieur interne : 000A58 ( Main/Exploration ); précédent : 000A57; suivant : 000A59Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis
Auteurs : Jiwon M. Lee [Corée du Sud] ; Andreas Kronbichler [Autriche] ; Se Jin Park [Corée du Sud] ; Seong Heon Kim [Corée du Sud] ; Kyoung Hee Han [Corée du Sud] ; Hee Gyung Kang [Corée du Sud] ; Il Soo Ha [Corée du Sud] ; Hae Il Cheong [Corée du Sud] ; Ki Hwan Kim [Corée du Sud] ; Gaeun Kim [Corée du Sud] ; Dong Soo Kim [Corée du Sud] ; Hyun Wook Chae [Corée du Sud] ; Chul Ho Lee [Corée du Sud] ; Keum Hwa Lee [Corée du Sud] ; Jae Il Shin [Corée du Sud]Source :
- Disease Markers [ 0278-0240 ] ; 2019.
Abstract
Matrix metalloproteinase (MMP) is an emerging disease marker in rheumatic diseases. This is a meta-analysis aimed at systematically reviewing association between serum MMP-3 levels and systematic lupus erythematosus (SLE) activity, which sought to raise interest in MMP-3 as a putative biomarker.
We conducted a meta-analysis of serum MMP-3 levels in patients with SLE and controls. We performed a PubMed search, EMBASE search, and forward search of the retrieved articles published until Oct. 1, 2018. In addition to this, we included data from a case-control study on a national pediatric SLE cohort, in which serum MMP-3 levels were measured in 11 SLE patients and 9 controls (unpublished). Subgroup analyses based on gender and disease activity were performed.
A total of 662 cases and 771 controls including 651 patients and 762 controls from 11 publications were studied. We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (
Our meta-analysis demonstrated significantly higher MMP-3 levels in SLE patients than in controls and in patients with renal involvement than in those without.
Url:
DOI: 10.1155/2019/9796735
PubMed: 31396295
PubMed Central: 6668546
Affiliations:
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Lee</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pediatrics, Chungnam National University Hospital, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Chungnam National University Hospital, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kronbichler, Andreas" sort="Kronbichler, Andreas" uniqKey="Kronbichler A" first="Andreas" last="Kronbichler">Andreas Kronbichler</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Park, Se Jin" sort="Park, 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type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Ha, Il Soo" sort="Ha, Il Soo" uniqKey="Ha I" first="Il Soo" last="Ha">Il Soo Ha</name><affiliation wicri:level="3"><nlm:aff id="I6">Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Seoul National University Children's Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cheong, Hae Il" sort="Cheong, Hae Il" uniqKey="Cheong H" first="Hae Il" last="Cheong">Hae Il Cheong</name><affiliation wicri:level="3"><nlm:aff id="I6">Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Seoul National University Children's Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Ki Hwan" sort="Kim, Ki Hwan" uniqKey="Kim K" first="Ki Hwan" last="Kim">Ki Hwan Kim</name><affiliation wicri:level="3"><nlm:aff id="I7">Department of Pediatrics, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Gaeun" sort="Kim, Gaeun" uniqKey="Kim G" first="Gaeun" last="Kim">Gaeun Kim</name><affiliation wicri:level="1"><nlm:aff id="I8">Keimyung University College of Nursing, Daegu, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Keimyung University College of Nursing, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Dong Soo" sort="Kim, Dong Soo" uniqKey="Kim D" first="Dong Soo" last="Kim">Dong Soo Kim</name><affiliation wicri:level="3"><nlm:aff id="I9">Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Chae, Hyun Wook" sort="Chae, Hyun Wook" uniqKey="Chae H" first="Hyun Wook" last="Chae">Hyun Wook 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Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Keum Hwa" sort="Lee, Keum Hwa" uniqKey="Lee K" first="Keum Hwa" last="Lee">Keum Hwa Lee</name><affiliation wicri:level="3"><nlm:aff id="I9">Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Shin, Jae Il" sort="Shin, Jae Il" uniqKey="Shin J" first="Jae Il" last="Shin">Jae Il Shin</name><affiliation wicri:level="3"><nlm:aff id="I9">Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of 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Lee</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pediatrics, Chungnam National University Hospital, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Chungnam National University Hospital, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kronbichler, Andreas" sort="Kronbichler, Andreas" uniqKey="Kronbichler A" first="Andreas" last="Kronbichler">Andreas Kronbichler</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Park, Se Jin" sort="Park, Se Jin" uniqKey="Park S" first="Se Jin" last="Park">Se Jin Park</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seong Heon" sort="Kim, Seong Heon" uniqKey="Kim S" first="Seong Heon" last="Kim">Seong Heon Kim</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Pusan National University Children's Hospital, Yangsan</wicri:regionArea><wicri:noRegion>Yangsan</wicri:noRegion></affiliation></author><author><name sortKey="Han, Kyoung Hee" sort="Han, Kyoung Hee" uniqKey="Han K" first="Kyoung Hee" last="Han">Kyoung Hee Han</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Pediatrics, Jeju National University School of Medicine, Jeju, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Jeju National University School of Medicine, Jeju</wicri:regionArea><wicri:noRegion>Jeju</wicri:noRegion></affiliation></author><author><name sortKey="Kang, Hee Gyung" sort="Kang, Hee Gyung" uniqKey="Kang H" first="Hee Gyung" last="Kang">Hee Gyung Kang</name><affiliation wicri:level="3"><nlm:aff id="I6">Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Seoul National University Children's Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Ha, Il Soo" sort="Ha, Il Soo" uniqKey="Ha I" first="Il Soo" last="Ha">Il Soo Ha</name><affiliation wicri:level="3"><nlm:aff id="I6">Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Seoul National University Children's Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cheong, Hae Il" sort="Cheong, Hae Il" uniqKey="Cheong H" first="Hae Il" last="Cheong">Hae Il Cheong</name><affiliation wicri:level="3"><nlm:aff id="I6">Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Seoul National University Children's Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Ki Hwan" sort="Kim, Ki Hwan" uniqKey="Kim K" first="Ki Hwan" last="Kim">Ki Hwan Kim</name><affiliation wicri:level="3"><nlm:aff id="I7">Department of Pediatrics, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Gaeun" sort="Kim, Gaeun" uniqKey="Kim G" first="Gaeun" last="Kim">Gaeun Kim</name><affiliation wicri:level="1"><nlm:aff id="I8">Keimyung University College of Nursing, Daegu, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Keimyung University College of Nursing, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Dong Soo" sort="Kim, Dong Soo" uniqKey="Kim D" first="Dong Soo" last="Kim">Dong Soo Kim</name><affiliation wicri:level="3"><nlm:aff id="I9">Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Chae, Hyun Wook" sort="Chae, Hyun Wook" uniqKey="Chae H" first="Hyun Wook" last="Chae">Hyun Wook Chae</name><affiliation wicri:level="3"><nlm:aff id="I9">Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Chul Ho" sort="Lee, Chul Ho" uniqKey="Lee C" first="Chul Ho" last="Lee">Chul Ho Lee</name><affiliation wicri:level="3"><nlm:aff id="I9">Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Keum Hwa" sort="Lee, Keum Hwa" uniqKey="Lee K" first="Keum Hwa" last="Lee">Keum Hwa Lee</name><affiliation wicri:level="3"><nlm:aff id="I9">Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Shin, Jae Il" sort="Shin, Jae Il" uniqKey="Shin J" first="Jae Il" last="Shin">Jae Il Shin</name><affiliation wicri:level="3"><nlm:aff id="I9">Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I10">Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatric Nephrology, Severance Children's Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I11">Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Disease Markers</title><idno type="ISSN">0278-0240</idno><idno type="eISSN">1875-8630</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p> Matrix metalloproteinase (MMP) is an emerging disease marker in rheumatic diseases. This is a meta-analysis aimed at systematically reviewing association between serum MMP-3 levels and systematic lupus erythematosus (SLE) activity, which sought to raise interest in MMP-3 as a putative biomarker. </p></sec><sec><title>Methods</title><p> We conducted a meta-analysis of serum MMP-3 levels in patients with SLE and controls. We performed a PubMed search, EMBASE search, and forward search of the retrieved articles published until Oct. 1, 2018. In addition to this, we included data from a case-control study on a national pediatric SLE cohort, in which serum MMP-3 levels were measured in 11 SLE patients and 9 controls (unpublished). Subgroup analyses based on gender and disease activity were performed. </p></sec><sec><title>Results</title><p> A total of 662 cases and 771 controls including 651 patients and 762 controls from 11 publications were studied. We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (<italic>P</italic> < 0.001, Hedges' <italic>g</italic>: 2.104, 95% CI 1.426-2.782). In subgroup analyses, we found a significant elevation of MMP-3 in the patients with nephritis compared to those without (<italic>P</italic> = 0.006, Hedges' <italic>g</italic>: 0.611, 95% CI 0.611-1.704). This finding was consistent between patients with persistent proteinuria and those without (<italic>P</italic> = 0.023, Hedges' <italic>g</italic>: 1.535, 95% CI 0.207-2.862). Meta-analysis showed no association between MMP-3 levels and gender or anti-double strand DNA antibody titer. </p></sec><sec><title>Conclusions</title><p> Our meta-analysis demonstrated significantly higher MMP-3 levels in SLE patients than in controls and in patients with renal involvement than in those without.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cook, H T" uniqKey="Cook H">H. T. Cook</name></author><author><name sortKey="Botto, M" uniqKey="Botto M">M. Botto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kotajima, L" uniqKey="Kotajima L">L. Kotajima</name></author><author><name sortKey="Aotsuka, S" uniqKey="Aotsuka S">S. Aotsuka</name></author><author><name sortKey="Fujimani, M" uniqKey="Fujimani M">M. Fujimani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Q Q" uniqKey="Zhu Q">Q. Q. 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Lee</name></noRegion><name sortKey="Chae, Hyun Wook" sort="Chae, Hyun Wook" uniqKey="Chae H" first="Hyun Wook" last="Chae">Hyun Wook Chae</name><name sortKey="Cheong, Hae Il" sort="Cheong, Hae Il" uniqKey="Cheong H" first="Hae Il" last="Cheong">Hae Il Cheong</name><name sortKey="Ha, Il Soo" sort="Ha, Il Soo" uniqKey="Ha I" first="Il Soo" last="Ha">Il Soo Ha</name><name sortKey="Han, Kyoung Hee" sort="Han, Kyoung Hee" uniqKey="Han K" first="Kyoung Hee" last="Han">Kyoung Hee Han</name><name sortKey="Kang, Hee Gyung" sort="Kang, Hee Gyung" uniqKey="Kang H" first="Hee Gyung" last="Kang">Hee Gyung Kang</name><name sortKey="Kim, Dong Soo" sort="Kim, Dong Soo" uniqKey="Kim D" first="Dong Soo" last="Kim">Dong Soo Kim</name><name sortKey="Kim, Gaeun" sort="Kim, Gaeun" uniqKey="Kim G" first="Gaeun" last="Kim">Gaeun Kim</name><name sortKey="Kim, Ki Hwan" sort="Kim, Ki Hwan" uniqKey="Kim K" first="Ki Hwan" last="Kim">Ki Hwan Kim</name><name sortKey="Kim, Seong Heon" sort="Kim, Seong Heon" uniqKey="Kim S" first="Seong Heon" last="Kim">Seong Heon Kim</name><name sortKey="Lee, Chul Ho" sort="Lee, Chul Ho" uniqKey="Lee C" first="Chul Ho" last="Lee">Chul Ho Lee</name><name sortKey="Lee, Keum Hwa" sort="Lee, Keum Hwa" uniqKey="Lee K" first="Keum Hwa" last="Lee">Keum Hwa Lee</name><name sortKey="Park, Se Jin" sort="Park, Se Jin" uniqKey="Park S" first="Se Jin" last="Park">Se Jin Park</name><name sortKey="Shin, Jae Il" sort="Shin, Jae Il" uniqKey="Shin J" first="Jae Il" last="Shin">Jae Il Shin</name><name sortKey="Shin, Jae Il" sort="Shin, Jae Il" uniqKey="Shin J" first="Jae Il" last="Shin">Jae Il Shin</name><name sortKey="Shin, Jae Il" sort="Shin, Jae Il" uniqKey="Shin J" first="Jae Il" last="Shin">Jae Il Shin</name></country><country name="Autriche"><noRegion><name sortKey="Kronbichler, Andreas" sort="Kronbichler, Andreas" uniqKey="Kronbichler A" first="Andreas" last="Kronbichler">Andreas Kronbichler</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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